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-Structure paper
タイトル | An icosahedral algal virus has a complex unique vertex decorated by a spike. |
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ジャーナル・号・ページ | Proc Natl Acad Sci U S A, Vol. 106, Issue 27, Page 11085-11089, Year 2009 |
掲載日 | 2009年7月7日 |
![]() | Mickaël V Cherrier / Victor A Kostyuchenko / Chuan Xiao / Valorie D Bowman / Anthony J Battisti / Xiaodong Yan / Paul R Chipman / Timothy S Baker / James L Van Etten / Michael G Rossmann / ![]() |
PubMed 要旨 | Paramecium bursaria Chlorella virus-1 is an icosahedrally shaped, 1,900-A-diameter virus that infects unicellular eukaryotic green algae. A 5-fold symmetric, 3D reconstruction using cryoelectron ...Paramecium bursaria Chlorella virus-1 is an icosahedrally shaped, 1,900-A-diameter virus that infects unicellular eukaryotic green algae. A 5-fold symmetric, 3D reconstruction using cryoelectron microscopy images has now shown that the quasiicosahedral virus has a unique vertex, with a pocket on the inside and a spike structure on the outside of the capsid. The pocket might contain enzymes for use in the initial stages of infection. The unique vertex consists of virally coded proteins, some of which have been identified. Comparison of shape, size, and location of the spike with similar features in bacteriophages T4 and P22 suggests that the spike might be a cell-puncturing device. Similar asymmetric features may have been missed in previous analyses of many other viruses that had been assumed to be perfectly icosahedral. |
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手法 | EM (単粒子) |
解像度 | 22.0 Å |
構造データ | ![]() EMDB-1597: |