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-Structure paper
タイトル | Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 19, Page 4034-4041, Year 2009 |
掲載日 | 2009年6月4日 (構造データの登録日) |
![]() | Shi, Y. / Zhang, J. / Shi, M. / O'Connor, S.P. / Bisaha, S.N. / Li, C. / Sitkoff, D. / Pudzianowski, A.T. / Chong, S. / Klei, H.E. ...Shi, Y. / Zhang, J. / Shi, M. / O'Connor, S.P. / Bisaha, S.N. / Li, C. / Sitkoff, D. / Pudzianowski, A.T. / Chong, S. / Klei, H.E. / Kish, K. / Yanchunas, J. / Liu, E.C. / Hartl, K.S. / Seiler, S.M. / Steinbacher, T.E. / Schumacher, W.A. / Atwal, K.S. / Stein, P.D. |
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手法 | X線回折 |
解像度 | 2.19 Å |
構造データ | ![]() PDB-3hpt: |
化合物 | ![]() ChemComp-GOL: ![]() ChemComp-YET: ![]() ChemComp-CA: ![]() ChemComp-NA: ![]() ChemComp-MES: ![]() ChemComp-ACT: ![]() ChemComp-DMS: ![]() ChemComp-HOH: |
由来 |
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![]() | HYDROLASE / BLOOD CLOTTING / SERINE PROTEASE / EPIDERMAL GROWTH FACTOR LIKE DOMAIN / BLOOD COAGULATION FACTOR / CLEAVAGE ON PAIR OF BASIC RESIDUES / EGF-LIKE DOMAIN / GAMMA-CARBOXYGLUTAMIC ACID / GLYCOPROTEIN / HYDROXYLATION / ZYMOGEN / Blood coagulation / Disulfide bond / Protease / Secreted |