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-Structure paper
Title | Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 4391-4399, Year 2009 |
Publish date | Feb 25, 2009 (structure data deposition date) |
Authors | Keough, D.T. / Hockova, D. / Holy, A. / Naesens, L.M. / Skinner-Adams, T.S. / Jersey, J. / Guddat, L.W. |
External links | J. Med. Chem. / PubMed:19527031 |
Methods | X-ray diffraction |
Resolution | 2.6 - 2.78 Å |
Structure data | PDB-3gep: PDB-3ggc: PDB-3ggj: |
Chemicals | ChemComp-24H: ChemComp-HOH: ChemComp-H26: ChemComp-25H: |
Source |
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Keywords | TRANSFERASE / phosphoribosyltransferase / acyclic nucleoside phosphonate / purine salvage pathway / malarial chemotherapeutic / Acetylation / Cytoplasm / Disease mutation / Glycosyltransferase / Gout / Magnesium / Metal-binding / Purine salvage / anti-malarial chemotherapeutic |