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TitleStabilising the DNA-Binding Domain of P53 by Rational Design of its Hydrophobic Core.
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 22, Page 421-, Year 2009
Publish dateApr 27, 2009 (structure data deposition date)
AuthorsKhoo, K.H. / Joerger, A.C. / Freund, S.M.V. / Fersht, A.R.
External linksProtein Eng. Des. Sel. / PubMed:19515728
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-2wgx:
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y236F-N239Y-T253I-N268D
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / P53 / P63 / P73 / CANCER / NUCLEUS / APOPTOSIS / TUMOR SUPPRESSOR / SECOND-SITE SUPPRESSOR MUTATION / DNA-BINDING DOMAIN / TRANSCRIPTION REGULATION / NUCLEAR PROTEIN / PROTEIN STABILIZATION / LI-FRAUMENI SYNDROME / METAL BINDING / ZINC / SUPERSTABLE MUTANT / DNA-BINDING PROTEIN / POLYMORPHISM

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