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TitleSubstituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 4350-4353, Year 2009
Publish dateMay 15, 2009 (structure data deposition date)
AuthorsShaw, A.N. / Tedesco, R. / Bambal, R. / Chai, D. / Concha, N.O. / Darcy, M.G. / Dhanak, D. / Duffy, K.J. / Fitch, D.M. / Gates, A. ...Shaw, A.N. / Tedesco, R. / Bambal, R. / Chai, D. / Concha, N.O. / Darcy, M.G. / Dhanak, D. / Duffy, K.J. / Fitch, D.M. / Gates, A. / Johnston, V.K. / Keenan, R.M. / Lin-Goerke, J. / Liu, N. / Sarisky, R.T. / Wiggall, K.J. / Zimmerman, M.N.
External linksBioorg. Med. Chem. Lett. / PubMed:19515564
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-3hhk:
HCV NS5b polymerase complex with a substituted benzothiadizine
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-77Z:
2-({(3R)-3-[(3S)-1-(3-methylbutyl)-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl]-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl}oxy)acetamide

ChemComp-HOH:
WATER

Source
  • hepatitis c virus subtype 1b
KeywordsHYDROLASE/HYDROLASE Inhibitor / NS5b / polymerase / HCV / inhhibitor / ATP-binding / Envelope protein / Helicase / Hydrolase / Membrane / Nucleotide-binding / RNA replication / Transmembrane / HYDROLASE-HYDROLASE Inhibitor COMPLEX

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