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TitleStructural basis for resistance of the genotype 2b hepatitis C virus NS5B polymerase to site A non-nucleoside inhibitors.
Journal, issue, pagesJ. Mol. Biol., Vol. 390, Page 1048-1059, Year 2009
Publish dateMar 27, 2009 (structure data deposition date)
AuthorsRydberg, E.H. / Cellucci, A. / Bartholomew, L. / Mattu, M. / Barbato, G. / Ludmerer, S.W. / Graham, D.J. / Altamura, S. / Paonessa, G. / De Francesco, R. ...Rydberg, E.H. / Cellucci, A. / Bartholomew, L. / Mattu, M. / Barbato, G. / Ludmerer, S.W. / Graham, D.J. / Altamura, S. / Paonessa, G. / De Francesco, R. / Migliaccio, G. / Carfi, A.
External linksJ. Mol. Biol. / PubMed:19505479
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3gsz:
Structure of the genotype 2B HCV polymerase
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • hepatitis c virus isolate hc-j8
KeywordsTRANSFERASE / polymerase / HCV

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