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Structure paper

TitleStructural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Journal, issue, pagesNat. Immunol., Vol. 10, Page 721-727, Year 2009
Publish dateMay 13, 2009 (structure data deposition date)
AuthorsRooijakkers, S.H. / Wu, J. / Ruyken, M. / van Domselaar, R. / Planken, K.L. / Tzekou, A. / Ricklin, D. / Lambris, J.D. / Janssen, B.J. / van Strijp, J.A. / Gros, P.
External linksNat. Immunol. / PubMed:19503103
MethodsX-ray diffraction
Resolution3.9 Å
Structure data

PDB-2win:
C3 convertase (C3bBb) stabilized by SCIN
Method: X-RAY DIFFRACTION / Resolution: 3.9 Å

Chemicals

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-MG:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • staphylococcus aureus (bacteria)
KeywordsIMMUNE SYSTEM / SERINE PROTEASE / IMMUNE RESPONSE / INNATE IMMUNITY / ZYMOGEN / SECRETED / PROTEASE / GLYCATION / ALTERNATIVE PATHWAY / DISEASE MUTATION / HYDROLASE / CONVERTASE / COMPLEMENT / POLYMORPHISM / IMMUNE EVASION

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