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TitleStructural and Functional Analysis of Sulfolobus Solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde-Deoxyguanosine Adduct.
Journal, issue, pagesBiochemistry, Vol. 48, Page 7079-, Year 2009
Publish dateSep 26, 2008 (structure data deposition date)
AuthorsEoff, R.L. / Stafford, J.B. / Szekely, J. / Rizzo, C.J. / Egli, M. / Guengerich, F.P. / Marnett, L.J.
External linksBiochemistry / PubMed:19492857
MethodsX-ray diffraction
Resolution2.5 - 2.6 Å
Structure data

PDB-2v4q:
Post-insertion complex of the Y-family DNA polymerase Dpo4 with M1dG containing template DNA
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2v4r:
Non-productive complex of the Y-family DNA polymerase Dpo4 with dGTP skipping the M1dG adduct to pair with the next template cytosine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-DGT:
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • sulfolobus solfataricus (archaea)
  • synthetic construct (others)
KeywordsTRANSFERASE / DNA-DIRECTED DNA POLYMERASE / DNA-BINDING / METAL-BINDING / DNA REPLICATION / MUTATOR PROTEIN / NUCLEOTIDYLTRANSFERASE / DNA ADDUCT / DNA DAMAGE / DNA REPAIR / DPO4 / M1DG / CYTOPLASM / MAGNESIUM / POLYMERASE

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