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TitleBacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Journal, issue, pagesCancer Res., Vol. 69, Page 4791-4799, Year 2009
Publish dateFeb 9, 2009 (structure data deposition date)
AuthorsFuchita, M. / Ardiani, A. / Zhao, L. / Serve, K. / Stoddard, B.L. / Black, M.E.
External linksCancer Res. / PubMed:19487291
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3g77:
Bacterial cytosine deaminase V152A/F316C/D317G mutant
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-FE:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / cytosine deaminase / protein engineering / Cytosine metabolism / Iron / Metal-binding

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