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TitleSimultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand-binding site
Journal, issue, pagesJ. Mol. Recognit., Vol. 22, Page 437-445, Year 2009
Publish dateApr 14, 2009 (structure data deposition date)
AuthorsSingh, N. / Kumar, R.P. / Kumar, S. / Sharma, S. / Mir, R. / Kaur, P. / Srinivasan, A. / Singh, T.P.
External linksJ. Mol. Recognit. / PubMed:19462410
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-3h1x:
Simultaneous inhibition of anti-coagulation and inflammation: Crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand binding site
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-IMN:
INDOMETHACIN / medication, antiinflammatory*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • daboia russellii russellii (snake)
KeywordsHYDROLASE / PLA2 / Anti-inflammatory / Anti-coagulant / Indomethacin

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