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Structure paper

TitleINT131: a selective modulator of PPAR gamma.
Journal, issue, pagesJ. Mol. Biol., Vol. 386, Page 1301-1311, Year 2009
Publish dateJan 14, 2009 (structure data deposition date)
AuthorsMotani, A. / Wang, Z. / Weiszmann, J. / McGee, L.R. / Lee, G. / Liu, Q. / Staunton, J. / Fang, Z. / Fuentes, H. / Lindstrom, M. ...Motani, A. / Wang, Z. / Weiszmann, J. / McGee, L.R. / Lee, G. / Liu, Q. / Staunton, J. / Fang, Z. / Fuentes, H. / Lindstrom, M. / Liu, J. / Biermann, D.H. / Jaen, J. / Walker, N.P. / Learned, R.M. / Chen, J.L. / Li, Y.
External linksJ. Mol. Biol. / PubMed:19452630
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3fur:
Crystal Structure of PPARg in complex with INT131
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-Z12:
2,4-dichloro-N-[3,5-dichloro-4-(quinolin-3-yloxy)phenyl]benzenesulfonamide

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION/Transcription regulator / nuclear receptor / PPARgamma / partial agonist / Activator / Alternative splicing / Diabetes mellitus / Disease mutation / DNA-binding / Metal-binding / Nucleus / Obesity / Phosphoprotein / Polymorphism / Receptor / Transcription / Transcription regulation / Zinc / Zinc-finger / INT131 / TRANSCRIPTION-Transcription regulator COMPLEX

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