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| Title | From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 106, Page 9820-9825, Year 2009 |
| Publish date | Apr 17, 2009 (structure data deposition date) |
 Authors | Chan, J.C. / Piper, D.E. / Cao, Q. / Liu, D. / King, C. / Wang, W. / Tang, J. / Liu, Q. / Higbee, J. / Xia, Z. ...Chan, J.C. / Piper, D.E. / Cao, Q. / Liu, D. / King, C. / Wang, W. / Tang, J. / Liu, Q. / Higbee, J. / Xia, Z. / Di, Y. / Shetterly, S. / Arimura, Z. / Salomonis, H. / Romanow, W.G. / Thibault, S.T. / Zhang, R. / Cao, P. / Yang, X.P. / Yu, T. / Lu, M. / Retter, M.W. / Kwon, G. / Henne, K. / Pan, O. / Tsai, M.M. / Fuchslocher, B. / Yang, E. / Zhou, L. / Lee, K.J. / Daris, M. / Sheng, J. / Wang, Y. / Shen, W.D. / Yeh, W.C. / Emery, M. / Walker, N.P. / Shan, B. / Schwarz, M. / Jackson, S.M. |
 External links | Proc. Natl. Acad. Sci. USA / PubMed:19443683 |
| Methods | X-ray diffraction |
| Resolution | 2.3 Å |
| Structure data |  PDB-3h42: |
| Chemicals |  ChemComp-NA:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE/IMMUNE SYSTEM / Hydrolase / Protein Fab Complex / Autocatalytic cleavage / Cholesterol metabolism / Disease mutation / Disulfide bond / Glycoprotein / Lipid metabolism / Phosphoprotein / Protease / Secreted / Serine protease / Steroid metabolism / Zymogen / HYDROLASE-IMMUNE SYSTEM COMPLEX |
homo sapiens (human)