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-Structure paper
| Title | Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13 |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 52, Page 3523-3538, Year 2009 |
| Publish date | Sep 22, 2008 (structure data deposition date) |
 Authors | Monovich, L.G. / Tommasi, R.A. / Fujimoto, R.A. / Blancuzzi, V. / Clark, K. / Cornell, W.D. / Doti, R. / Doughty, J. / Fang, J. / Farley, D. ...Monovich, L.G. / Tommasi, R.A. / Fujimoto, R.A. / Blancuzzi, V. / Clark, K. / Cornell, W.D. / Doti, R. / Doughty, J. / Fang, J. / Farley, D. / Fitt, J. / Ganu, V. / Goldberg, R. / Goldstein, R. / Lavoie, S. / Kulathila, R. / Macchia, W. / Parker, D.T. / Melton, R. / O'Byrne, E. / Pastor, G. / Pellas, T. / Quadros, E. / Reel, N. / Roland, D.M. / Sakane, Y. / Singh, H. / Skiles, J. / Somers, J. / Toscano, K. / Wigg, A. / Zhou, S. / Zhu, L. / Shieh, W.C. / Xue, S. / McQuire, L.W. |
 External links | J. Med. Chem. / PubMed:19422229 |
| Methods | X-ray diffraction |
| Resolution | 1.9 Å |
| Structure data |  PDB-3elm: |
| Chemicals |  ChemComp-ZN:  ChemComp-CA:  ChemComp-24F:  ChemComp-HOH: |
| Source |
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 Keywords | HYDROLASE / metallo-enzyme / MMP-13 / carboxylate inhibitor / Calcium / Collagen degradation / Disease mutation / Extracellular matrix / Glycoprotein / Metal-binding / Metalloprotease / Polymorphism / Protease / Secreted / Zinc / Zymogen |
homo sapiens (human)