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TitleDiscovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 3136-3140, Year 2009
Publish dateOct 7, 2008 (structure data deposition date)
AuthorsPatnaik, S. / Stevens, K.L. / Gerding, R. / Deanda, F. / Shotwell, J.B. / Tang, J. / Hamajima, T. / Nakamura, H. / Leesnitzer, M.A. / Hassell, A.M. ...Patnaik, S. / Stevens, K.L. / Gerding, R. / Deanda, F. / Shotwell, J.B. / Tang, J. / Hamajima, T. / Nakamura, H. / Leesnitzer, M.A. / Hassell, A.M. / Shewchuck, L.M. / Kumar, R. / Lei, H. / Chamberlain, S.D.
External linksBioorg. Med. Chem. Lett. / PubMed:19394223
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-3eta:
Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-351:
1-(3-{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / TRANSFERASE / ATP-binding / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Glycoprotein / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Receptor / Transmembrane / Tyrosine-protein kinase

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