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Structure paper

TitleAlpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function
Journal, issue, pagesOrg. Lett., Vol. 11, Page 1883-1886, Year 2009
Publish dateFeb 24, 2009 (structure data deposition date)
AuthorsUpton, T.G. / Kashemirov, B.A. / McKenna, C.E. / Goodman, M.F. / Prakash, G.K. / Kultyshev, R. / Batra, V.K. / Shock, D.D. / Pedersen, L.C. / Beard, W.A. / Wilson, S.H.
External linksOrg. Lett. / PubMed:19351147
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3gdx:
Dna polymerase beta with a gapped DND substrate and dTMP(CF2)PP
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-4BD:
5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]thymidine

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / NUCLOETIDYL TRANSFERASE / DNA POLYMERASE / DNA damage / DNA repair / DNA replication / DNA synthesis / DNA-binding / DNA-directed DNA polymerase / Lyase / Magnesium / Metal-binding / Nucleotidyltransferase / Nucleus / Polymorphism / Sodium / Transferase / TRANSFERASE-DNA COMPLEX

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