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Structure paper

TitleMolecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 14177-, Year 2009
Publish dateMar 6, 2009 (structure data deposition date)
AuthorsManolopoulou, M. / Guo, Q. / Malito, E. / Schilling, A.B. / Tang, W.J.
External linksJ. Biol. Chem. / PubMed:19321446
MethodsX-ray diffraction
Resolution2.6 - 2.8 Å
Structure data

PDB-2wby:
Crystal structure of human insulin-degrading enzyme in complex with insulin
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2wc0:
crystal structure of human insulin degrading enzyme in complex with iodinated insulin
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HORMONE / GLUCOSE METABOLISM / CARBOHYDRATE METABOLISM / DISEASE MUTATION / DIABETES MELLITUS / ZINC / DIOXANE / INSULIN / HORMONE / SECRETED / PROTEASE / DISULFIDE BOND / PHARMACEUTICAL / METALLOPROTEASE / HUMAN INSULIN-DEGRADNG ENZYME / HYDROLASE / CYTOPLASM / POLYMORPHISM / METAL-BINDING / CLEAVAGE ON PAIR OF BASIC RESIDUES / HYDROLASE-HORMONE complex / HUMAN INSULIN-DEGRADING ENZYME

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