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TitleStructure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.
Journal, issue, pagesScience, Vol. 323, Issue 5920, Page 1477-1481, Year 2009
Publish dateMar 13, 2009
AuthorsFranz Herzog / Ivana Primorac / Prakash Dube / Peter Lenart / Björn Sander / Karl Mechtler / Holger Stark / Jan-Michael Peters /
PubMed AbstractOnce all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its ...Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its coactivator Cdc20 (APC/C(Cdc20)). Before chromosome biorientation, anaphase is delayed by a mitotic checkpoint complex (MCC) that inhibits APC/C(Cdc20). We used single-particle electron microscopy to obtain three-dimensional models of human APC/C in various functional states: bound to MCC, to Cdc20, or to neither (apo-APC/C). These experiments revealed that MCC associates with the Cdc20 binding site on APC/C, locks the otherwise flexible APC/C in a "closed" state, and prevents binding and ubiquitylation of a wide range of different APC/C substrates. These observations clarify the structural basis for the inhibition of APC/C by spindle checkpoint proteins.
External linksScience / PubMed:19286556 / PubMed Central
MethodsEM (single particle)
Resolution20.0 Å
Structure data

EMDB-1591:
Structure of the anaphase promoting complex interacting with a mitotic checkpoint complex
Method: EM (single particle) / Resolution: 20.0 Å

EMDB-1592:
Structure of the anaphase promoting complex interacting with a mitotic checkpoint complex
Method: EM (single particle) / Resolution: 20.0 Å

Source
  • Homo sapiens (human)

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