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-Structure paper
Title | Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 2277-2281, Year 2009 |
Publish date | Apr 2, 2009 (structure data deposition date) |
![]() | Gellibert, F. / Fouchet, M.-H. / Nguyen, V.-L. / Wang, R. / Krysa, G. / de Gouville, A.-C. / Huet, S. / Dodic, N. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 1.8 Å |
Structure data | ![]() PDB-3gxl: ![]() PDB-3hmm: |
Chemicals | ![]() ChemComp-QIG: ![]() ChemComp-HOH: ![]() ChemComp-855: |
Source |
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![]() | TRANSFERASE / TGF-beta / Alk5 / kinase / inhibitor / quinazoline / Aortic aneurysm / ATP-binding / Craniosynostosis / Disease mutation / Disulfide bond / Glycoprotein / Magnesium / Manganese / Membrane / Metal-binding / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Serine/threonine-protein kinase / Transmembrane / PHOSPHOPROTEIN POLYMORPHISM |