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TitleComparative analysis of mutant tyrosine kinase chemical rescue.
Journal, issue, pagesBiochemistry, Vol. 48, Page 3378-3386, Year 2009
Publish dateFeb 25, 2009 (structure data deposition date)
AuthorsMuratore, K.E. / Seeliger, M.A. / Wang, Z. / Fomina, D. / Neiswinger, J. / Havranek, J.J. / Baker, D. / Kuriyan, J. / Cole, P.A.
External linksBiochemistry / PubMed:19260709
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-3geq:
Structural basis for the chemical rescue of Src kinase activity
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-PP2:
1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

ChemComp-HOH:
WATER

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / Kinase / chemical rescue / PP2 / Alternative splicing / ATP-binding / Lipoprotein / Myristate / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase

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