+検索条件
-Structure paper
タイトル | Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. |
---|---|
ジャーナル・号・ページ | J. Med. Chem., Vol. 52, Page 1814-1827, Year 2009 |
掲載日 | 2008年10月29日 (構造データの登録日) |
![]() | Qian, K. / Wang, L. / Cywin, C.L. / Farmer, B.T. / Hickey, E. / Homon, C. / Jakes, S. / Kashem, M.A. / Lee, G. / Leonard, S. ...Qian, K. / Wang, L. / Cywin, C.L. / Farmer, B.T. / Hickey, E. / Homon, C. / Jakes, S. / Kashem, M.A. / Lee, G. / Leonard, S. / Li, J. / Magboo, R. / Mao, W. / Pack, E. / Peng, C. / Prokopowicz, A. / Welzel, M. / Wolak, J. / Morwick, T. |
![]() | ![]() ![]() |
手法 | X線回折 |
解像度 | 1.9 Å |
構造データ | ![]() PDB-3f2a: |
化合物 | ![]() ChemComp-985: ![]() ChemComp-MG: ![]() ChemComp-HOH: |
由来 |
|
![]() | TRANSFERASE / potein kinase fold / Alternative initiation / ATP-binding / Cell membrane / Cytoplasm / Kinase / Manganese / Membrane / Metal-binding / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Proto-oncogene / Serine/threonine-protein kinase |