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Structure paper

TitleStructural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 106, Page 4665-4670, Year 2009
Publish dateOct 1, 2008 (structure data deposition date)
AuthorsPazgier, M. / Liu, M. / Zou, G. / Yuan, W. / Li, C. / Li, J. / Monbo, J. / Zella, D. / Tarasov, S.G. / Lu, W.
External linksProc. Natl. Acad. Sci. USA / PubMed:19255450
MethodsX-ray diffraction
Resolution1.63 - 1.65 Å
Structure data

PDB-3eqs:
Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-3eqy:
Crystal structure of human MDMX in complex with a 12-mer peptide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.63 Å

Chemicals

ChemComp-GAI:
GUANIDINE

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsLIGASE / MDM2 / MDM2-peptide inhibitor complex / oncoprotein / Host-virus interaction / Metal-binding / Nucleus / Phosphoprotein / Proto-oncogene / Ubl conjugation pathway / Zinc-finger / MDM4 / MDMX / MDMX-peptide inhibitor complex

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