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TitleMeropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
Journal, issue, pagesScience, Vol. 323, Page 1215-1218, Year 2009
Publish dateJul 23, 2008 (structure data deposition date)
AuthorsHugonnet, J.E. / Tremblay, L.W. / Boshoff, H.I. / Barry, C.E. / Blanchard, J.S.
External linksScience / PubMed:19251630
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-3dwz:
Meropenem Covalent Adduct with TB Beta-lactamase
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-DWZ:
(2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid / antibiotic*YM

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsHYDROLASE/ANTIBIOTIC / alpha-beta folded protein / protein-covalent adduct / Antibiotic resistance / Hydrolase / Lipoprotein / Membrane / Palmitate / Meropenem (open form) / HYDROLASE-ANTIBIOTIC COMPLEX

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