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TitleTriad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Journal, issue, pagesProtein Sci., Vol. 18, Page 569-578, Year 2009
Publish dateJan 21, 2009 (structure data deposition date)
AuthorsOlland, A.M. / Strand, J. / Presman, E. / Czerwinski, R. / Joseph-McCarthy, D. / Krykbaev, R. / Schlingmann, G. / Chopra, R. / Lin, L. / Fleming, M. ...Olland, A.M. / Strand, J. / Presman, E. / Czerwinski, R. / Joseph-McCarthy, D. / Krykbaev, R. / Schlingmann, G. / Chopra, R. / Lin, L. / Fleming, M. / Kriz, R. / Stahl, M. / Somers, W. / Fitz, L. / Mosyak, L.
External linksProtein Sci. / PubMed:19241384
MethodsX-ray diffraction
Resolution1.7 - 2 Å
Structure data

PDB-3fxy:
Acidic Mammalian Chinase, Catalytic Domain
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3fy1:
The Acidic Mammalian Chitinase catalytic domain in complex with methylallosamidin
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-AMI:
ALLOSAMIZOLINE

Source
  • homo sapiens (human)
KeywordsHYDROLASE / CHITINASE / ASTHMA / CHITIN DEGRADATION / Alternative splicing / Carbohydrate metabolism / Chitin-binding / Cytoplasm / Glycosidase / Polymorphism / Polysaccharide degradation / Secreted / INHIBITOR / METHYLALLOSAMIDIN

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