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Structure paper

TitleStructural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Journal, issue, pagesAcs Chem. Biol., Vol. 4, Page 289-, Year 2009
Publish dateApr 1, 2009 (structure data deposition date)
AuthorsProdromou, C. / Nuttall, J.M. / Millson, S.H. / Roe, S.M. / Sim, T.S. / Tan, D. / Workman, P. / Pearl, L.H. / Piper, P.W.
External linksAcs Chem. Biol. / PubMed:19236053
MethodsX-ray diffraction
Resolution1.6 - 2.2 Å
Structure data

PDB-2wep:
Yeast Hsp90 N-terminal domain LI-IV mutant with ADP
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2weq:
Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2wer:
Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-GDM:
GELDANAMYCIN / antitumor, antibiotic*YM

ChemComp-GOL:
GLYCEROL

ChemComp-RDC:
RADICICOL

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsCHAPERONE / ATPASE / ATP-BINDING / PHOSPHOPROTEIN / STRESS RESPONSE / NUCLEOTIDE-BINDING / CYTOPLASM

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