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-Structure paper
Title | Crystallographic and cellular characterisation of two mechanisms stabilising the native fold of alpha1-antitrypsin: implications for disease and drug design. |
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Journal, issue, pages | J. Mol. Biol., Vol. 387, Page 857-868, Year 2009 |
Publish date | Jul 11, 2008 (structure data deposition date) |
Authors | Gooptu, B. / Miranda, E. / Nobeli, I. / Mallya, M. / Purkiss, A. / Brown, S.C. / Summers, C. / Phillips, R.L. / Lomas, D.A. / Barrett, T.E. |
External links | J. Mol. Biol. / PubMed:19232354 |
Methods | X-ray diffraction |
Resolution | 2.2 - 3.2 Å |
Structure data | PDB-3drm: PDB-3dru: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | Hydrolase inhibitor / serpin / serine proteinase inhibitor / alpha1-antitrypsin / polymerisation / rational drug design / conformational disease / emphysema / cirrhosis / Acute phase / Alternative splicing / Blood coagulation / Disease mutation / Glycoprotein / Hydrolase / Polymorphism / Protease / Protease inhibitor / Secreted / Serine protease inhibitor |