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TitleAntagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 10561-10570, Year 2009
Publish dateFeb 22, 2009 (structure data deposition date)
AuthorsMcNutt, M.C. / Kwon, H.J. / Chen, C. / Chen, J.R. / Horton, J.D. / Lagace, T.A.
External linksJ. Biol. Chem. / PubMed:19224862
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3gcw:
PCSK9:EGFA(H306Y)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3gcx:
PCSK9:EGFA (pH 7.4)
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / PCSK9 / LDL receptor / Autocatalytic cleavage / Cholesterol metabolism / Disease mutation / Glycoprotein / Hydrolase / Lipid metabolism / Phosphoprotein / Protease / Secreted / Serine protease / Steroid metabolism / Zymogen / Coated pit / EGF-like domain / Endocytosis / Host-virus interaction / LDL / Lipid transport / Membrane / Receptor / Transmembrane / Transport

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