+検索条件
-Structure paper
タイトル | Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. |
---|---|
ジャーナル・号・ページ | J. Med. Chem., Vol. 52, Page 1255-1258, Year 2009 |
掲載日 | 2009年1月8日 (構造データの登録日) |
著者 | Li, H. / Tatlock, J. / Linton, A. / Gonzalez, J. / Jewell, T. / Patel, L. / Ludlum, S. / Drowns, M. / Rahavendran, S.V. / Skor, H. ...Li, H. / Tatlock, J. / Linton, A. / Gonzalez, J. / Jewell, T. / Patel, L. / Ludlum, S. / Drowns, M. / Rahavendran, S.V. / Skor, H. / Hunter, R. / Shi, S.T. / Herlihy, K.J. / Parge, H. / Hickey, M. / Yu, X. / Chau, F. / Nonomiya, J. / Lewis, C. |
リンク | J. Med. Chem. / PubMed:19209845 |
手法 | X線回折 |
解像度 | 1.86 Å |
構造データ | PDB-3frz: |
化合物 | ChemComp-AG0: ChemComp-AG6: ChemComp-BME: ChemComp-HOH: |
由来 |
|
キーワード | TRANSFERASE / viral polymerase / Acetylation / Apoptosis / ATP-binding / Capsid protein / Cell membrane / Cytoplasm / Endoplasmic reticulum / Envelope protein / Fusion protein / Glycoprotein / Helicase / Host-virus interaction / Hydrolase / Interferon antiviral system evasion / Lipid droplet / Lipoprotein / Membrane / Metal-binding / Mitochondrion / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus / Oncogene / Palmitate / Phosphoprotein / Protease / Ribonucleoprotein / RNA replication / RNA-binding / RNA-directed RNA polymerase / Secreted / Serine protease / SH3-binding / Thiol protease / Transcription / Transcription regulation / Transmembrane / Ubl conjugation / Viral nucleoprotein / Virion / Zinc |