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-Structure paper
Title | Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 1357-1360, Year 2009 |
Publish date | Jan 8, 2009 (structure data deposition date) |
Authors | Nishimura, T. / Iino, T. / Mitsuya, M. / Bamba, M. / Watanabe, H. / Tsukahara, D. / Kamata, K. / Sasaki, K. / Ohyama, S. / Hosaka, H. ...Nishimura, T. / Iino, T. / Mitsuya, M. / Bamba, M. / Watanabe, H. / Tsukahara, D. / Kamata, K. / Sasaki, K. / Ohyama, S. / Hosaka, H. / Futamura, M. / Nagata, Y. / Eiki, J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:19188063 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-3fr0: |
Chemicals | ChemComp-GLC: ChemComp-AJB: ChemComp-NA: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Hexokinase IV / Allosteric enzyme / Diabetes / Alternative splicing / ATP-binding / Diabetes mellitus / Disease mutation / Glycolysis / Kinase / Nucleotide-binding / Polymorphism |