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Structure paper

TitleCrystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.
Journal, issue, pagesFebs J., Vol. 276, Page 793-806, Year 2009
Publish dateAug 5, 2008 (structure data deposition date)
AuthorsRedzynia, I. / Ljunggren, A. / Bujacz, A. / Abrahamson, M. / Jaskolski, M. / Bujacz, G.
External linksFebs J. / PubMed:19143838
MethodsX-ray diffraction
Resolution1.86 Å
Structure data

PDB-3e1z:
Crystal structure of the parasite protesase inhibitor chagasin in complex with papain
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-FMT:
FORMIC ACID

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

Source
  • trypanosoma cruzi (eukaryote)
  • carica papaya (papaya)
KeywordsHYDROLASE INHIBITOR/HYDROLASE / chagasin-papain complex / papain / Chagas disease / cysteine proteinases / protein inhibitors / Cytoplasmic vesicle / Protease inhibitor / Thiol protease inhibitor / Allergen / Hydrolase / Protease / Thiol protease / Zymogen / HYDROLASE INHIBITOR-HYDROLASE COMPLEX

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