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TitleAnalysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 5723-, Year 2009
Publish dateJul 30, 2008 (structure data deposition date)
AuthorsLi, S. / Ouellet, H. / Sherman, D.H. / Podust, L.M.
External linksJ. Biol. Chem. / PubMed:19124459
MethodsX-ray diffraction
Resolution1.85 - 3.2 Å
Structure data

PDB-2vz7:
Crystal structure of the YC-17-bound PikC D50N mutant
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-2vzm:
Crystal structure of the narbomycin-bound PikC D50N mutant
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-PXI:
4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE

ChemComp-HOH:
WATER

ChemComp-NRB:
NARBOMYCIN

Source
  • streptomyces venezuelae (bacteria)
KeywordsOXIDOREDUCTASE / ANTIBIOTIC BIOSYNTHESIS / PIKC / IRON / HEME / CYP107L1 / MONOOXYGENASE / MACROLIDE MONOOXYGENASE / METAL-BINDING / CYTOCHROME P450

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