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-Structure paper
Title | Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference. |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 322-328, Year 2009 |
Publish date | Nov 3, 2008 (structure data deposition date) |
Authors | Temperini, C. / Cecchi, A. / Scozzafava, A. / Supuran, C.T. |
External links | J. Med. Chem. / PubMed:19115843 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3f4x: |
Chemicals | ChemComp-ZN: ChemComp-HG: ChemComp-KLT: ChemComp-HOH: |
Source |
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Keywords | LYASE / carbonic anhydrase / inhibitors / diuretics / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc |