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Structure paper

TitleStructure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Journal, issue, pagesMol. Cell, Vol. 32, Page 849-861, Year 2008
Publish dateNov 22, 2008 (structure data deposition date)
AuthorsZhu, J. / Luo, B.H. / Xiao, T. / Zhang, C. / Nishida, N. / Springer, T.A.
External linksMol. Cell / PubMed:19111664
MethodsX-ray diffraction
Resolution2.55 - 2.9 Å
Structure data

PDB-3fcs:
Structure of complete ectodomain of integrin aIIBb3
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-3fcu:
Structure of headpiece of integrin aIIBb3 in open conformation
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-IMD:
IMIDAZOLE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CAC:
CACODYLATE ION

Source
  • homo sapiens (human)
KeywordsCell Adhesion/BLOOD CLOTTING / beta propeller / rossmann fold / egf domain / Cell adhesion / Disease mutation / Glycoprotein / Host-virus interaction / Integrin / Membrane / Phosphoprotein / Receptor / Transmembrane / Cell Adhesion-immune System COMPLEX / Cell Adhesion-BLOOD CLOTTING COMPLEX / CRYSTAL STRUCTURE; PLATELET INTEGRIN ALPHAIIBBETA3; FIBRINOGEN BINDING; ALLOSTERY; THERAPEUTIC ANTAGONISM

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