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-Structure paper
Title | Crystal Structures of Human Delta4-3-Ketosteroid 5beta-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substrate Inhibition (dagger) (,) (double dagger). |
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Journal, issue, pages | Biochemistry, Vol. 47, Page 13537-13546, Year 2008 |
Publish date | Feb 20, 2008 (structure data deposition date) |
Authors | Faucher, F. / Cantin, L. / Luu-The, V. / Labrie, F. / Breton, R. |
External links | Biochemistry / PubMed:19075558 |
Methods | X-ray diffraction |
Resolution | 2 - 2.2 Å |
Structure data | PDB-3caq: PDB-3cas: |
Chemicals | ChemComp-NDP: ChemComp-BME: ChemComp-EDO: ChemComp-MPD: ChemComp-HOH: ChemComp-NAP: ChemComp-ASD: |
Source |
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Keywords | OXIDOREDUCTASE / 5b-reductase / 5beta-reductase / 5b-red / AKR1D1 / AKR / aldo-keto reductase / NADP / androstenedione / NADPH / 5b-dhp / substrate inhibition / Bile acid catabolism / Cytoplasm / Disease mutation / Lipid metabolism / Steroid metabolism |