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Structure paper

TitleThe fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Journal, issue, pagesCell Host Microbe, Vol. 4, Page 567-578, Year 2008
Publish dateOct 31, 2008 (structure data deposition date)
AuthorsYu, M. / Kumar, T.R. / Nkrumah, L.J. / Coppi, A. / Retzlaff, S. / Li, C.D. / Kelly, B.J. / Moura, P.A. / Lakshmanan, V. / Freundlich, J.S. ...Yu, M. / Kumar, T.R. / Nkrumah, L.J. / Coppi, A. / Retzlaff, S. / Li, C.D. / Kelly, B.J. / Moura, P.A. / Lakshmanan, V. / Freundlich, J.S. / Valderramos, J.C. / Vilcheze, C. / Siedner, M. / Tsai, J.H. / Falkard, B. / Sidhu, A.B. / Purcell, L.A. / Gratraud, P. / Kremer, L. / Waters, A.P. / Schiehser, G. / Jacobus, D.P. / Janse, C.J. / Ager, A. / Jacobs, W.R. / Sacchettini, J.C. / Heussler, V. / Sinnis, P. / Fidock, D.A.
External linksCell Host Microbe / PubMed:19064257
MethodsX-ray diffraction
Resolution2.49 Å
Structure data

PDB-3f4b:
Crystal structure of Plasmodium berghei Enoyl-acyl-carrier-protein reductase with TRICLOSAN
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-TCL:
TRICLOSAN

ChemComp-HOH:
WATER

Source
  • plasmodium berghei (eukaryote)
KeywordsOXIDOREDUCTASE / PbENR / PbFabI / triclosan

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