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TitleDiscovery of a novel series of quinoxalines as inhibitors of c-Met kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 397-400, Year 2009
Publish dateNov 5, 2008 (structure data deposition date)
AuthorsPorter, J. / Lumb, S. / Lecomte, F. / Reuberson, J. / Foley, A. / Calmiano, M. / le Riche, K. / Edwards, H. / Delgado, J. / Franklin, R.J. ...Porter, J. / Lumb, S. / Lecomte, F. / Reuberson, J. / Foley, A. / Calmiano, M. / le Riche, K. / Edwards, H. / Delgado, J. / Franklin, R.J. / Gascon-Simorte, J.M. / Maloney, A. / Meier, C. / Batchelor, M.
External linksBioorg. Med. Chem. Lett. / PubMed:19059779
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-3f66:
Human c-Met Kinase in complex with quinoxaline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-IHX:
3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol

ChemComp-GBL:
GAMMA-BUTYROLACTONE

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / c-Met / protein kinase / quinoxaline / Alternative splicing; ATP-binding; Chromosomal rearrangement; Disease mutation; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.

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