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Structure paper

TitleMolecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
Journal, issue, pagesFebs Lett., Vol. 582, Page 4089-4094, Year 2008
Publish dateNov 18, 2008 (structure data deposition date)
AuthorsKasper, C. / Frydenvang, K. / Naur, P. / Gajhede, M. / Pickering, D.S. / Kastrup, J.S.
External linksFebs Lett. / PubMed:19022251
MethodsX-ray diffraction
Resolution1.4 - 1.9 Å
Structure data

PDB-3fas:
X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-glutamate at 1.40A resolution
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-3fat:
X-ray structure of iGluR4 flip ligand-binding core (S1S2) in complex with (S)-AMPA at 1.90A resolution
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-AMQ:
(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID / neurotransmitter, agonist*YM

ChemComp-ACY:
ACETIC ACID

Source
  • rattus norvegicus (Norway rat)
KeywordsMEMBRANE PROTEIN / ionotropic glutamate receptors / iGluR4 / flip / ligand-binding core / agonist complex

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