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-Structure paper
Title | Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 19, Page 226-229, Year 2009 |
Publish date | Jul 18, 2008 (structure data deposition date) |
![]() | Tecle, H. / Shao, J. / Li, Y. / Kothe, M. / Kazmirski, S. / Penzotti, J. / Ding, Y.H. / Ohren, J. / Moshinsky, D. / Coli, R. ...Tecle, H. / Shao, J. / Li, Y. / Kothe, M. / Kazmirski, S. / Penzotti, J. / Ding, Y.H. / Ohren, J. / Moshinsky, D. / Coli, R. / Jhawar, N. / Bora, E. / Jacques-O'Hagan, S. / Wu, J. |
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Methods | X-ray diffraction |
Resolution | 2.3 - 2.7 Å |
Structure data | ![]() PDB-3dv3: ![]() PDB-3dy7: |
Chemicals | ![]() ChemComp-MG: ![]() ChemComp-ATP: ![]() ChemComp-MEK: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-1CX: |
Source |
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![]() | TRANSFERASE / Kinase / Kinase inhibitors / MEK / ATP-binding / Disease mutation / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase / Tyrosine-protein kinase / dual specificity protein kinase / non-ATP-competitive kinase inhibitor / inhibitor-bound protein kinase / ATP-bound protein kinase / Acetylation |