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Structure paper

TitleCrystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 284-291, Year 2009
Publish dateNov 4, 2008 (structure data deposition date)
AuthorsWilliams, N.K. / Lucet, I.S. / Klinken, S.P. / Ingley, E. / Rossjohn, J.
External linksJ. Biol. Chem. / PubMed:18984583
MethodsX-ray diffraction
Resolution2.5 - 2.76 Å
Structure data

PDB-2zv7:
Lyn Tyrosine Kinase Domain, apo form
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-2zv8:
Lyn Tyrosine Kinase Domain-AMP-PNP complex
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-2zv9:
Lyn Tyrosine Kinase Domain-PP2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.76 Å

PDB-2zva:
Lyn Tyrosine Kinase Domain-Dasatinib complex
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-PP2:
1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE

ChemComp-1N1:
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE / medication*YM

Source
  • mus musculus (house mouse)
KeywordsTRANSFERASE / Lyn Kinase / Alternative splicing / ATP-binding / Kinase / Lipoprotein / Myristate / Nucleotide-binding / Palmitate / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase / Lyn Kinase AMPPNP / Lyn Kinase PP2 / Lyn Kinase dasatinib

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