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Structure paper

TitleLesion bypass of N2-ethylguanine by human DNA polymerase iota.
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 1732-1740, Year 2009
Publish dateSep 29, 2008 (structure data deposition date)
AuthorsPence, M.G. / Blans, P. / Zink, C.N. / Hollis, T. / Fishbein, J.C. / Perrino, F.W.
External linksJ. Biol. Chem. / PubMed:18984581
MethodsX-ray diffraction
Resolution2.5 - 2.9 Å
Structure data

PDB-3epg:
Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-3epi:
Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine and incoming TTP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / DNA pol iota / lesion bypass / N2-ethylguanine / DNA damage / DNA repair / DNA replication / DNA synthesis / DNA-binding / DNA-directed DNA polymerase / Magnesium / Metal-binding / Mutator protein / Nucleotidyltransferase / Nucleus / Schiff base / Transferase / TRANSFERASE-DNA COMPLEX

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