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-Structure paper
| Title | Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation. |
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| Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 6071-6077, Year 2008 |
| Publish date | Oct 7, 2008 (structure data deposition date) |
 Authors | Walker, D.P. / Bi, F.C. / Kalgutkar, A.S. / Bauman, J.N. / Zhao, S.X. / Soglia, J.R. / Aspnes, G.E. / Kung, D.W. / Klug-McLeod, J. / Zawistoski, M.P. ...Walker, D.P. / Bi, F.C. / Kalgutkar, A.S. / Bauman, J.N. / Zhao, S.X. / Soglia, J.R. / Aspnes, G.E. / Kung, D.W. / Klug-McLeod, J. / Zawistoski, M.P. / McGlynn, M.A. / Oliver, R. / Dunn, M. / Li, J.C. / Richter, D.T. / Cooper, B.A. / Kath, J.C. / Hulford, C.A. / Autry, C.L. / Luzzio, M.J. / Ung, E.J. / Roberts, W.G. / Bonnette, P.C. / Buckbinder, L. / Mistry, A. / Griffor, M.C. / Han, S. / Guzman-Perez, A. |
 External links | Bioorg. Med. Chem. Lett. / PubMed:18951788 |
| Methods | X-ray diffraction |
| Resolution | 2.7 Å |
| Structure data |  PDB-3et7: |
| Chemicals |  ChemComp-349:  ChemComp-PO4:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / TRANSFERASE / kinase / Alternative splicing / ATP-binding / Cell membrane / Cytoplasm / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Tyrosine-protein kinase |
homo sapiens (human)