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TitleInhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 7053-7056, Year 2008
Publish dateOct 1, 2007 (structure data deposition date)
AuthorsRose, N.R. / Ng, S.S. / Mecinovic, J. / Lienard, B.M. / Bello, S.H. / Sun, Z. / McDonough, M.A. / Oppermann, U. / Schofield, C.J.
External linksJ. Med. Chem. / PubMed:18942826
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-2vd7:
Crystal Structure of JMJD2A complexed with inhibitor Pyridine-2,4- dicarboxylic acid
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-ZN:
Unknown entry

ChemComp-PD2:
PYRIDINE-2,4-DICARBOXYLIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / PHOSPHORYLATION / CHROMATIN REGULATOR / IRON / NUCLEUS / ZINC-FINGER / DIOXYGENASE / HOST-VIRUS INTERACTION / TRANSCRIPTION REGULATION / TRANSCRIPTION / METAL-BINDING / HISTONE DEMETHYLATION INHIBITOR JMJC DOMAIN

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