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-Structure paper
Title | Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: exploration of P1 phenoxy and benzyloxy residues |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 16, Page 9471-9486, Year 2008 |
Publish date | Jun 30, 2008 (structure data deposition date) |
Authors | Back, M. / Nyhlen, J. / Kvarnstrom, I. / Appelgren, S. / Borkakoti, N. / Jansson, K. / Lindberg, J. / Nystrom, S. / Hallberg, A. / Rosenquist, S. / Samuelsson, B. |
External links | Bioorg. Med. Chem. / PubMed:18842420 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-3dm6: |
Chemicals | ChemComp-757: ChemComp-IPA: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / BACE / beta-secretase / statine / inhibitor / Alternative splicing / Aspartyl protease / Glycoprotein / Membrane / Protease / Transmembrane / Zymogen |