+検索条件
-Structure paper
タイトル | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. |
---|---|
ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 18, Page 5809-5814, Year 2008 |
掲載日 | 2008年8月20日 (構造データの登録日) |
![]() | Mazzola, R.D. / Zhu, Z. / Sinning, L. / McKittrick, B. / Lavey, B. / Spitler, J. / Kozlowski, J. / Neng-Yang, S. / Zhou, G. / Guo, Z. ...Mazzola, R.D. / Zhu, Z. / Sinning, L. / McKittrick, B. / Lavey, B. / Spitler, J. / Kozlowski, J. / Neng-Yang, S. / Zhou, G. / Guo, Z. / Orth, P. / Madison, V. / Sun, J. / Lundell, D. / Niu, X. |
![]() | ![]() ![]() |
手法 | X線回折 |
解像度 | 1.9 Å |
構造データ | ![]() PDB-3e8r: ![]() PDB-3edz: |
化合物 | ![]() ChemComp-ZN: ![]() ChemComp-615: ![]() ChemComp-INN: ![]() ChemComp-CIT: ![]() ChemComp-HOH: ![]() ChemComp-550: |
由来 |
|
![]() | HYDROLASE / TACE ADAM17 ZN-Endopeptidase / Cleavage on pair of basic residues / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Notch signaling pathway / Phosphoprotein / Protease / SH3-binding / Transmembrane / Zymogen / ZN-ENDOPEPTIDASE |