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-Structure paper
Title | Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 5809-5814, Year 2008 |
Publish date | Aug 20, 2008 (structure data deposition date) |
Authors | Mazzola, R.D. / Zhu, Z. / Sinning, L. / McKittrick, B. / Lavey, B. / Spitler, J. / Kozlowski, J. / Neng-Yang, S. / Zhou, G. / Guo, Z. ...Mazzola, R.D. / Zhu, Z. / Sinning, L. / McKittrick, B. / Lavey, B. / Spitler, J. / Kozlowski, J. / Neng-Yang, S. / Zhou, G. / Guo, Z. / Orth, P. / Madison, V. / Sun, J. / Lundell, D. / Niu, X. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18835710 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3e8r: PDB-3edz: |
Chemicals | ChemComp-ZN: ChemComp-615: ChemComp-INN: ChemComp-CIT: ChemComp-HOH: ChemComp-550: |
Source |
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Keywords | HYDROLASE / TACE ADAM17 ZN-Endopeptidase / Cleavage on pair of basic residues / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Notch signaling pathway / Phosphoprotein / Protease / SH3-binding / Transmembrane / Zymogen / ZN-ENDOPEPTIDASE |