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TitleDiscovery and X-ray Crystallographic Analysis of a Iminohydantoin Inhibitor of beta-Secretase
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 6259-6262, Year 2008
Publish dateDec 17, 2008 (structure data deposition date)
AuthorsBarrow, J.C. / Stauffer, S.R. / Rittle, K.E. / Ngo, P.L. / Yang, M.S. / Graham, S. / McGaughey, G. / Holloway, K. / Tugusheva, S.K. / Lai, M. ...Barrow, J.C. / Stauffer, S.R. / Rittle, K.E. / Ngo, P.L. / Yang, M.S. / Graham, S. / McGaughey, G. / Holloway, K. / Tugusheva, S.K. / Lai, M. / Espeseth, A.S. / Xu, M. / Huang, Q. / Zuck, P. / Levorse, D.A. / Hazuda, D. / Vacca, J.P.
External linksJ. Med. Chem. / PubMed:18811140
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3fkt:
Crystal Structure of Human Beta Secretase Complexed with Spiropiperdine Iminohydantoin Inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-SII:
N-(4-{[4-(cyclohexylamino)-1-(3-fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-8-yl]methyl}phenyl)acetamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / ASPARTYL PROTEASE / BACE / Alternative splicing / Glycoprotein / Membrane / Polymorphism / Protease / Transmembrane / Zymogen

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