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Structure paper

TitleActivation of tyrosine kinases by mutation of the gatekeeper threonine.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 15, Page 1109-1118, Year 2008
Publish dateJul 9, 2008 (structure data deposition date)
AuthorsAzam, M. / Seeliger, M.A. / Gray, N.S. / Kuriyan, J. / Daley, G.Q.
External linksNat. Struct. Mol. Biol. / PubMed:18794843
MethodsX-ray diffraction
Resolution2.017 - 2.3 Å
Structure data

PDB-3dqw:
c-Src kinase domain Thr338Ile mutant in complex with ATPgS
Method: X-RAY DIFFRACTION / Resolution: 2.017 Å

PDB-3dqx:
chicken c-Src kinase domain in complex with ATPgS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-AGS:
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER / ATP-gamma-S, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-AMP:
ADENOSINE MONOPHOSPHATE / AMP*YM

Source
  • gallus gallus (chicken)
KeywordsTRANSFERASE / SRC / KINASE / ACTIVE / GATEKEEPER / ATP-binding / Lipoprotein / Myristate / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase

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