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Structure paper

TitleStructural insights into intermediate steps in the Sir2 deacetylation reaction.
Journal, issue, pagesStructure, Vol. 16, Page 1368-1377, Year 2008
Publish dateMay 14, 2008 (structure data deposition date)
AuthorsHawse, W.F. / Hoff, K.G. / Fatkins, D.G. / Daines, A. / Zubkova, O.V. / Schramm, V.L. / Zheng, W. / Wolberger, C.
External linksStructure / PubMed:18786399
MethodsX-ray diffraction
Resolution1.9 - 2.5 Å
Structure data

PDB-3d4b:
Crystal structure of Sir2Tm in complex with Acetyl p53 peptide and DADMe-NAD+
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3d81:
Sir2-S-alkylamidate complex crystal structure
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-DZD:
5'-O-[(R)-{[(R)-{[(3R,4R)-1-(3-carbamoylbenzyl)-4-hydroxypyrrolidin-3-yl]methoxy}(hydroxy)phosphoryl]methyl}(hydroxy)phosphoryl]adenosine

ChemComp-HOH:
WATER

Source
  • thermotoga maritima (bacteria)
KeywordsHYDROLASE / Rossmann Fold / Cytoplasm / Metal-binding / NAD / Zinc / NAD dependent deacetylase

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