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Structure paper

TitleStructural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Journal, issue, pagesCell(Cambridge,Mass. ), Vol. 134, Page 793-803, Year 2008
Publish dateDec 6, 2007 (structure data deposition date)
AuthorsFilippakopoulos, P. / Kofler, M. / Hantschel, O. / Gish, G.D. / Grebien, F. / Salah, E. / Neudecker, P. / Kay, L.E. / Turk, B.E. / Superti-Furga, G. ...Filippakopoulos, P. / Kofler, M. / Hantschel, O. / Gish, G.D. / Grebien, F. / Salah, E. / Neudecker, P. / Kay, L.E. / Turk, B.E. / Superti-Furga, G. / Pawson, T. / Knapp, S.
External linksCell(Cambridge,Mass. ) / PubMed:18775312
MethodsX-ray diffraction
Resolution1.75 - 1.98 Å
Structure data

PDB-3bkb:
Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-3cbl:
Crystal structure of human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-3cd3:
Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / FES / v-fes / Fujinami / avian sarcoma / viral / oncogene / feline sarcoma virus / SGC / Structural Genomics Consortium / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / Proto-oncogene / SH2 domain / Tyrosine-protein kinase / active

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