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Title | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 5522-5532, Year 2008 |
Publish date | Jun 2, 2008 (structure data deposition date) |
Authors | Folkes, A.J. / Ahmadi, K. / Alderton, W.K. / Alix, S. / Baker, S.J. / Box, G. / Chuckowree, I.S. / Clarke, P.A. / Depledge, P. / Eccles, S.A. ...Folkes, A.J. / Ahmadi, K. / Alderton, W.K. / Alix, S. / Baker, S.J. / Box, G. / Chuckowree, I.S. / Clarke, P.A. / Depledge, P. / Eccles, S.A. / Friedman, L.S. / Hayes, A. / Hancox, T.C. / Kugendradas, A. / Lensun, L. / Moore, P. / Olivero, A.G. / Pang, J. / Patel, S. / Pergl-Wilson, G.H. / Raynaud, F.I. / Robson, A. / Saghir, N. / Salphati, L. / Sohal, S. / Ultsch, M.H. / Valenti, M. / Wallweber, H.J.A. / Wan, N.C. / Wiesmann, C. / Workman, P. / Zhyvoloup, A. / Zvelebil, M.J. / Shuttleworth, S.J. |
External links | J. Med. Chem. / PubMed:18754654 |
Methods | X-ray diffraction |
Resolution | 2.8 Å |
Structure data | PDB-3dbs: |
Chemicals | ChemComp-GD9: |
Source |
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Keywords | TRANSFERASE / PI3K gamma / Inhibitor / Kinase |