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Structure paper

TitleInhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 105, Page 12803-, Year 2008
Publish dateJan 7, 2008 (structure data deposition date)
AuthorsJohansson, P. / Wiltschi, B. / Kumari, P. / Kessler, B. / Vonrhein, C. / Vonck, J. / Oesterhelt, D. / Grininger, M.
External linksProc. Natl. Acad. Sci. USA / PubMed:18725634
MethodsX-ray diffraction
Resolution4 Å
Structure data

PDB-2vkz:
Structure of the cerulenin-inhibited fungal fatty acid synthase type I multienzyme complex
Method: X-RAY DIFFRACTION / Resolution: 4 Å

Chemicals

ChemComp-CER:
(2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE / antifungal, antibiotic*YM

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSFERASE / PHOSPHORYLATION / PHOSPHOPANTETHEINE / FATTY ACID SYNTHASE / MULTIFUNCTIONAL ENZYME / OXIDOREDUCTASE / LIPID SYNTHESIS / FAS / NAD / NADP / LYASE / CERULENIN / HYDROLASE / FATTY ACID BIOSYNTHESIS

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